AMD192 GB VRAM5,300 GB/s$2.5/hr

Qwen 2.5 72B on AMD MI300X 192GB: Does It Fit, How Fast, What It Costs

Qwen 2.5 72B at FP8 (E4M3) needs 72.7 GB for its weights and 94.2 GB in total at 8K context with 8 concurrent users. That means it fits on a single AMD MI300X 192GB. Every figure is computed by tokcalc's open-source capacity model.

Fits?
Yes, 1 GPU
94.2 GB needed / 192 GB available
Decode speed
71.08
tok/s per stream
Aggregate
853.0
tok/s @ 8 concurrent
Cost / 1M tokens
$0.8142
1× AMD MI300X 192GB
What changes as you add AMD MI300X 192GBs
Tensor-parallel degree vs VRAM, throughput, and cost. Cost scales linearly with GPU count; decode throughput scales near-linearly too, so cost per token stays roughly flat.
GPUsTotal VRAMVRAM neededDecode tok/sAggregate tok/sTTFTCost / 1M tokFits?
1× AMD192 GB94.2 GB71.08853.01.87 s$0.8142✓
2× AMD384 GB94.2 GB120.82900949.6 ms$0.4789✓
4× AMD768 GB94.2 GB241.711600489.8 ms$0.2395✓
8× AMD1536 GB94.2 GB483.346401259.9 ms$0.1197✓
Concurrency vs context length
On 1× AMD MI300X 192GB at FP8 (E4M3). KV cache scales linearly with context, so this is the number of users your GPUs can actually serve.
ContextConcurrent usersKV per requestFits?
4K881.34 GB✓ fits
8K442.68 GB✓ fits
33K1110.74 GB✓ fits
66K521.47 GB✓ fits
131K242.95 GB✓ fits
Other GPUs that run Qwen 2.5 72B
Same workload, same quantization — ranked by value (tokens per dollar-hour).
GPUGPUsAggregate tok/sCost / 1M tok
RTX 5090 32GB4×3922$0.1416
A100 80GB SXM42×1094$0.6092
H100 SXM5 80GB2×1833$0.7577
L40S 48GB2×472.8$0.8226
AMD MI325X 288GB1×965.6$1.01
Intel Gaudi 3 128GB1×531.1$1.05
Frequently asked questions

Can Qwen 2.5 72B run on AMD MI300X 192GB?

Yes. Qwen 2.5 72B at FP8 (E4M3) needs 94.2 GB including the KV cache, and AMD MI300X 192GB has 192 GB — so it fits on a single GPU.

How fast is Qwen 2.5 72B on AMD MI300X 192GB?

71.08 tokens/sec per stream and 853.0 tok/s aggregate with continuous batching at 8 concurrent users. Time to first token is 1.87 s, and inter-token latency is 14.1 ms.

What does Qwen 2.5 72B on AMD MI300X 192GB cost per million tokens?

$0.8142 per 1M output tokens at 1× AMD MI300X 192GB ($2.50/hr). That is the marginal hardware cost — add idle capacity, ops, and egress for the real figure.

How much VRAM does Qwen 2.5 72B need on AMD MI300X 192GB?

72.7 GB for the weights at FP8 (E4M3), plus 21.5 GB of KV cache for 8 concurrent requests at 8K context — 94.2 GB total. Every extra concurrent user at long context costs more, so leave headroom.

Is AMD MI300X 192GB the right choice for Qwen 2.5 72B?

It works. Compare $0.8142 per 1M tokens against the alternatives below — the cheapest option that fits the same workload is 8× RTX 4080 16GB at $0.1062, and the fastest is 4× Cerebras CS-3 (WSE-3) at 43774 tok/s.

Adjust the workload yourself

Same formulas, your context length, concurrency, and quantisation.

Open in calculator